Immune imprinting and vaccine interval determine antibody responses to monovalent XBB.1.5 COVID-19 vaccination
Our findings indicate that immune imprinting continues to affect humoral immunity elicited by the XBB.1.5 vaccine. Both imprinting and exposure intervals are important phenomena underlying immunogenicity of future variant-adapted COVID-19 vaccines.
Authors
- Mila Trank-Greene (ORCID: https://orcid.org/0009-0000-4934-3811)
- Fikadu Tafesse (ORCID: https://orcid.org/0000-0002-8575-4164)
- Mastura Wahedi
- Xammy Nguyenla (ORCID: https://orcid.org/0000-0002-7532-8356)
- Timothy A. Bates (ORCID: https://orcid.org/0000-0002-2533-7668)
- Marcel E. Curlin (ORCID: https://orcid.org/0000-0003-3481-3889)
- Audrey Hinchliff (ORCID: https://orcid.org/0009-0008-5297-1657)
Institutions
- Oregon Health & Science University (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1038/s43856-025-00898-4
- Citations
- 5
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- Oregon Health and Science University
- National Institutes of Health