Cardiopulmonary remodeling following repetitive acute pulmonary emboli and inhibition of endogenous fibrinolysis in a porcine model
This porcine model using autologous pulmonary emboli presents a realistic large animal model of chronic thromboembolic pulmonary disease particularly suitable to further investigate the vascular remodeling after acute PE. Future research should examine the role of inflammation, endothelial dysfunction and angiogenesis-driven clot resolution to improve understanding of the pathophysiological mechanisms.
Authors
- Simone Juel Dragsbæk (ORCID: https://orcid.org/0000-0001-9021-8975)
- Anders Kramer (ORCID: https://orcid.org/0000-0002-5546-8693)
- Jacob Valentin Hansen (ORCID: https://orcid.org/0000-0002-7017-575X)
- C. Pedersen (ORCID: https://orcid.org/0000-0001-7481-1955)
- Takayuki Jujo (ORCID: https://orcid.org/0000-0001-5725-1810)
- Jacob Gammelgaard Schultz (ORCID: https://orcid.org/0000-0002-4374-1605)
- Victor Tang Merit (ORCID: https://orcid.org/0000-0002-4082-6718)
- Mathilde Emilie Kirk (ORCID: https://orcid.org/0000-0001-6245-2238)
- Mads Dam Lyhne (ORCID: https://orcid.org/0000-0001-5279-260X)
- Asger Andersen (ORCID: https://orcid.org/0000-0002-9102-3130)
- Lina Karout (ORCID: https://orcid.org/0000-0002-2179-7480)
- Mannudeep K. Kalra (ORCID: https://orcid.org/0000-0001-9938-7476)
- Jens Erik Nielsen-Kudsk
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- International Journal of Cardiology
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1016/j.ijcard.2025.133398
- Citations
- 4
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 7.48
Funders
- Hjerteforeningen
- Aarhus Universitet
- Institut for Klinisk Medicin, Aarhus Universitet
- Karen Elise Jensens Fond
- Laerdal Foundation for Acute Medicine