Blood-brain barrier permeability varies by brain region and APOE4 status and correlates with brain microstructure among high-AD risk groups
Individuals at greater genetic risk for AD demonstrate elevated cortical BBB permeability associated with microstructural abnormalities. These relationships were seen in a widespread spatial pattern that is dissimilar from the stereotypical spread of AD neuropathology.
Authors
- Qian Shen (ORCID: https://orcid.org/0000-0002-0410-9797)
- Seraphina K. Solders (ORCID: https://orcid.org/0000-0001-6329-987X)
- Emilie T. Reas (ORCID: https://orcid.org/0000-0002-4110-5154)
Institutions
- UC San Diego Health System (US)
- University of California San Diego (US)
Publication Details
- Journal
- NeuroImage Clinical
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.nicl.2025.103805
- Citations
- 3
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.29
Funders
- American Federation for Aging Research
- National Institutes of Health
- University of California, San Diego