Clinical and fertility outcomes in lynch syndrome patients with endometrial carcinoma or endometrial Intraepthelial neoplasia treated with fertility sparing management
Fertility sparing management for LS patients with an EIN or EC diagnosis is uncommon. Progesterone response rates appear to be lower than those in sporadic cases, though similar clinical and histologic factors (age, BMI, and p53 expression pattern) may predict disease regression and fertility outcomes. A larger sample and standardized treatment paradigm are needed to provide more evidence on fertility sparing management for LS patients.
Authors
- Mary Kathryn Abel (ORCID: https://orcid.org/0000-0003-0447-5823)
- Matthew B.B. Yurgelun (ORCID: https://orcid.org/0000-0002-6184-9273)
- David L. Kolin (ORCID: https://orcid.org/0000-0002-7631-6525)
- Colleen M. Feltmate (ORCID: https://orcid.org/0000-0002-7700-8575)
- Jessica D. St. Laurent (ORCID: https://orcid.org/0000-0002-9422-8713)
- Sophia H. Yin
- Isabela Covelli Velez
- Hadley Reid (ORCID: https://orcid.org/0000-0002-4329-7831)
- Elizabeth S. Ginsburg (ORCID: https://orcid.org/0000-0002-5206-1724)
- Alexandria N. Young
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- Gynecologic Oncology Reports
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1016/j.gore.2025.101768
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for Women's Cancer