OTUD3 inhibits breast cancer cell metastasis by regulating TGF-β pathway through deubiquitinating SMAD7
Our findings indicated OTUD3 inhibited BRCA metastasis associated with TGF-β signaling by deubiquitination to stabilize SMAD7 protein levels.
Authors
- Qianqian Zhao (ORCID: https://orcid.org/0000-0003-1384-1418)
- Chenchen Geng (ORCID: https://orcid.org/0000-0002-7495-9068)
- Junhua An
- Ziqian Liu (ORCID: https://orcid.org/0000-0001-8710-3464)
- Ke Dong (ORCID: https://orcid.org/0000-0002-8768-1034)
- Yanrong Lv (ORCID: https://orcid.org/0000-0001-6862-6788)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1186/s12935-025-03822-x
- Citations
- 4
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Shandong University
- Qilu Hospital of Shandong University
- Natural Science Foundation of Shandong Province