Water soluble peroral pharmaceutical form of phosphatidylcholine: experimental and clinical data in combined hyperlipidemia
This article discusses the role of phospholipids as a key component of high-density lipoproteins (HDL) involved in the reverse transport of cholesterol from cells with its subsequent excretion from the body. The results of the phospholipidation research on the capacity of HDL cholesterol efflux from macrophages, as well as an assessment of the hypolipidemic and antiatherogenic effects of phospholipids on an atherosclerosis rabbit model at the functional and morphological levels are presented. In phase I clinical trial the safety of the oral administration of the innovative water-soluble pharmaceutical form of phosphatidylcholine in healthy volunteers was proven. In a double-blind, placebo-controlled phase II-III clinical trial in patients with combined hyperlipidemia its efficacy in achieving of the non-HDL cholesterol and triglycerides therapeutic target and safety with long-term oral administration was demonstrated.
Authors
- Е. С. Тихонова (ORCID: https://orcid.org/0000-0001-8301-1028)
- В. В. Кухарчук (ORCID: https://orcid.org/0000-0002-7028-362X)
- М.Н. Гусева (ORCID: https://orcid.org/0000-0002-5576-6164)
- Е. А. Пономаренко (ORCID: https://orcid.org/0000-0002-9672-7145)
- С. В. Иванов (ORCID: https://orcid.org/0000-0003-0438-9108)
- Mariia Yu. Zubareva (ORCID: https://orcid.org/0000-0002-7050-9393)
- Yulia A. Romashova (ORCID: https://orcid.org/0000-0001-9580-0251)
- Vladimir Aleksandrovich Kutsenko (ORCID: https://orcid.org/0000-0001-9844-3122)
- А.В. Лисица (ORCID: https://orcid.org/0000-0003-1188-4270)
- O. M. Ipatova (ORCID: https://orcid.org/0000-0001-6285-1669)
- С. С. Маркин (ORCID: https://orcid.org/0000-0002-0242-0282)
- Alexander I. Archakov (ORCID: https://orcid.org/0000-0002-2290-8090)
- Е. B. Yarovaya (ORCID: https://orcid.org/0000-0002-6615-4315)
- В. В. Береговых (ORCID: https://orcid.org/0000-0002-0210-4570)
- Tatiana O. Pleshakova (ORCID: https://orcid.org/0000-0002-5435-5937)
Publication Details
- Journal
- Annals of the Russian academy of medical sciences
- Published
- 2025-05-17
- DOI
- https://doi.org/10.15690/vramn18026
- Citations
- 1
- Primary Topic
- Pharmacology and Obesity Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.39