BAX-mediated ammonia-driven cell death: a novel prognostic and therapeutic target in clear cell renal cell carcinoma
The ammonia-related cell death pathway, especially BAX, can be employed as a potential prognostic marker and therapeutic target for ccRCC, providing new ideas for individualized treatment strategies to overcome immunosuppression and improve clinical prognosis.
Authors
- Qiang Li (ORCID: https://orcid.org/0000-0003-0096-7679)
- Hongfei Wu (ORCID: https://orcid.org/0000-0001-6299-546X)
- Xiao‐Xu Zhu
- Heng Li (ORCID: https://orcid.org/0000-0003-2166-4116)
- Jian Li (ORCID: https://orcid.org/0000-0001-8415-4389)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-0422-8980)
- Shaohua He
- Yin Lu (ORCID: https://orcid.org/0000-0003-0633-7715)
- Zhigang Yu (ORCID: https://orcid.org/0000-0002-3093-4491)
- Hongqi Chen (ORCID: https://orcid.org/0000-0002-1137-5700)
- Lian Sheng
- Yang Lv
Institutions
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Human Genomics
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1186/s40246-025-00764-3
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Yunnan Provincial Department of Education