Effects of verapamil on intestinal injury in a rat model of acute mesenteric ischemia
Administering heparin and verapamil at the time of revascularization may mitigate intestinal IRI without causing detrimental systemic effects. Further studies in large animal models and in the setting of local administration are needed to investigate the potential of this approach.
Authors
- Jack Nelson
- Jonathan J. Morrison (ORCID: https://orcid.org/0000-0001-7462-8456)
- Patrick F. Walker (ORCID: https://orcid.org/0000-0002-0871-2702)
- Diego V.S. Rodrigues (ORCID: https://orcid.org/0000-0002-3132-541X)
- Silvana Wilken
- Julia Jacobs (ORCID: https://orcid.org/0000-0003-1164-4699)
- Colin Price
Institutions
- Mayo Clinic (US)
- Uniformed Services University of the Health Sciences (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Surgery in Practice and Science
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1016/j.sipas.2025.100286
- Citations
- 1
- Primary Topic
- Abdominal vascular conditions and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Mayo Clinic
- Deutsche Forschungsgemeinschaft