Single-cell transcriptomic insights into endosulfan-induced liver injury: Key pathways and inflammatory responses
This study provides new insights into the cellular and molecular mechanisms underlying liver injury induced by organochlorine insecticides like ENDO. Key genes and pathways involved in ENDO-associated liver toxicity have been identified at a single-cell resolution. These findings suggest that altered cellular communications and inflammatory responses may play pivotal roles in the pathogenesis of ENDO-induced liver injury.
Authors
- Wei Xü (ORCID: https://orcid.org/0000-0002-3135-5010)
- Chuanbin Yang (ORCID: https://orcid.org/0000-0001-8288-4038)
- Peng Chen (ORCID: https://orcid.org/0000-0003-3730-1846)
- Ashok Iyaswamy (ORCID: https://orcid.org/0000-0003-0186-3863)
- Chaohua Zhou
- Xiaoru Zhong
- Yunmeng Bai (ORCID: https://orcid.org/0000-0001-7915-4501)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-2235-1851)
- Jigang Wang (ORCID: https://orcid.org/0000-0002-0575-0105)
- Pan Huang (ORCID: https://orcid.org/0009-0007-8468-1227)
Institutions
- Hong Kong Baptist University (HK)
- Guangxi Medical University (CN)
- Guangdong Pharmaceutical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Southern University of Science and Technology (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- Karpagam Academy of Higher Education (IN)
Publication Details
- Journal
- Liver Research
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1016/j.livres.2025.05.002
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00