Whole body and hematopoietic cell-specific deletion of G-protein coupled receptor 65 (GPR65) improves insulin sensitivity in diet-induced obese mice

Our data suggests that macrophage-specific GPR65 signaling contributes to inflammation and the development of insulin resistance.

Authors

E. H. Bae
Samuel Klein (ORCID: https://orcid.org/0000-0001-7127-1156)
Samuel M. Hoffman
Gordon I. Smith (ORCID: https://orcid.org/0000-0003-0063-046X)
Saswata Talukdar (ORCID: https://orcid.org/0000-0003-3042-0025)
Da Young Oh
Yingjiang Zhou

Institutions

Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
Washington University in St. Louis (US)
Southwestern Medical Center (US)
Southwestern Medical Center (US)
Jeonbuk National University (KR)
The University of Texas Southwestern Medical Center (US)

Publication Details

Journal: Molecular Metabolism
Published: 2025-05-17
DOI: https://doi.org/10.1016/j.molmet.2025.102169
Primary Topic: Receptor Mechanisms and Signaling
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Merck
National Institute of Diabetes and Digestive and Kidney Diseases

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article

Whole body and hematopoietic cell-specific deletion of G-protein coupled receptor 65 (GPR65) improves insulin sensitivity in diet-induced obese mice

E. H. Bae, Samuel Klein, Samuel M. Hoffman, Gordon I. Smith et al.

May 17, 2025

Molecular Metabolism

Receptor Mechanisms and Signaling

article

Whole body and hematopoietic cell-specific deletion of G-protein coupled receptor 65 (GPR65) improves insulin sensitivity in diet-induced obese mice

E. H. Bae, Samuel Klein, Samuel M. Hoffman, Gordon I. Smith, Saswata Talukdar, Da Young Oh, Yingjiang Zhou

May 17, 2025article en

Abstract

Our data suggests that macrophage-specific GPR65 signaling contributes to inflammation and the development of insulin resistance.

Molecular MetabolismVol. 97

Merck & Co., Inc., Rahway, NJ, USA (United States) (US), Washington University in St. Louis (US), Southwestern Medical Center (US), Southwestern Medical Center (US), Jeonbuk National University (KR), The University of Texas Southwestern Medical Center (US)

Merck, National Institute of Diabetes and Digestive and Kidney Diseases

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Receptor Mechanisms and Signaling

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Whole body and hematopoietic cell-specific deletion of G-protein coupled receptor 65 (GPR65) improves insulin sensitivity in diet-induced obese mice — E. H. Bae, Samuel Klein, et al. · Molecular Metabolism (2025) | TGRS Research Map | TGRS