Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer
The Nrf2/HO-1 pathway is a significant contributor to cisplatin resistance in NSCLC. Targeting HO-1 with SB 202190 and NDGA presents a promising strategy to overcome resistance and improve chemotherapy outcomes.
Authors
- Ji‐Ye Yin (ORCID: https://orcid.org/0000-0002-1244-5045)
- Ding‐Chao Rong (ORCID: https://orcid.org/0009-0002-8414-7845)
- Xiaoye Zhang (ORCID: https://orcid.org/0000-0002-3580-8259)
- Peng‐Yuan Wang (ORCID: https://orcid.org/0000-0001-7965-2914)
- Huixiang Tian (ORCID: https://orcid.org/0009-0007-3632-636X)
- Lei‐Yun Wang
- Min Dong (ORCID: https://orcid.org/0000-0001-6429-3891)
- Yulong Zhang (ORCID: https://orcid.org/0000-0001-9020-7184)
- Zhao Zhang (ORCID: https://orcid.org/0000-0002-4293-8916)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-0284-9396)
- Jie Mei (ORCID: https://orcid.org/0000-0002-8221-199X)
- Haijun Wu (ORCID: https://orcid.org/0000-0001-7354-7101)
- Yang Gao (ORCID: https://orcid.org/0000-0003-4834-7997)
- Yinong Chen (ORCID: https://orcid.org/0000-0003-2329-0373)
- Jun Zeng (ORCID: https://orcid.org/0009-0001-4584-945X)
Institutions
- Central South University (CN)
- Guangxi Medical University (CN)
- Shaoyang University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- The Central Hospital of Shaoyang (CN)
- PharmacoGenetics (China) (CN)
- Xiangya Hospital Central South University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1016/j.jare.2025.05.033
- Citations
- 8
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- National Natural Science Foundation of China
- Central South University
- National Key Research and Development Program of China
- Natural Science Foundation of Zhejiang Province