Silencing hnRNPD inhibits gastric cancer growth by increasing TXNIP-mediated oxidative stress
Our study highlights hnRNPD as a major contributor to gastric carcinogenesis. The knockdown of hnRNPD hinders gastric cancer growth by directly interacting with TXNIP, promoting its expression, and inducing oxidative stress. These findings suggest that hnRNPD may serve as a valuable target for the treatment of gastric cancer.
Authors
- Xiaoyan Wang (ORCID: https://orcid.org/0000-0003-3359-1209)
- Kelong Wang (ORCID: https://orcid.org/0000-0002-5285-3940)
- Jian Zhou (ORCID: https://orcid.org/0000-0002-7650-7540)
- Jin Li (ORCID: https://orcid.org/0000-0003-3094-4777)
- Xuan Zou (ORCID: https://orcid.org/0009-0001-7345-9467)
- Qiulei Ren
Institutions
- Hubei University of Medicine (CN)
- Suizhou Central Hospital (CN)
- Taihe Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1007/s12672-025-02667-0
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00