Adipokine status in pregnant women with irritable bowel syndrome

Irritable bowel syndrome (IBS) refers to the disease whose course may be complicated with the onset of pregnancy due to physiological metabolic and adaptive changes to it. The study of concentrations of adipose tissue hormones - adipokines - may be useful for predicting the course of pregnancy and complications in women with IBS. Aim - to study the anamnesis and course of pregnancy in IBS women. Materials and methods. 154 women were examined (124 pregnant women from the study group, divided into 2 subgroups depending on the symptomatic/asymptomatic course of IBS; as well as 30 somatically healthy pregnant women from the control group) for anamnestic peculiarities and serum concentrations of chemerin, apelin and resistin. Statistical analysis and presentation of the results were done using the packages "MedStat" and "Microsoft Office Excel". The difference between groups was considered significant at p≤0.05. Results. During pregnancy an increase in the concentrations of serum pro-inflammatory adipokines is observed, which is a risk factor for exacerbations of IBS. Symptomatic course of IBS is observed in women with significantly higher concentrations of serum adipokines, risk of gestoses (preeclampsia, vomiting of pregnancy), gestational diabetes mellitus and miscarriage are also increased in these women. Conclusions. Serum concentrations of apelin, chemerin, and resistin in pregnant women can be used as markers predicting the symptomatic course of IBS and IBS itself also contributes to named adipokines elevation, which leads to higher pregnancy complications risk. The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the local ethics committee of the participating institution. Informed consent of the patients was obtained for the study. The authors declare no conflict of interest.