Management of recurrent HPV-associated cervical intraepithelial neoplasias in women of perimenopausal age

Aim: to increase the effectiveness of complex therapy of recurrence of cervical intraepithelial neoplasia (CIN) in women of perimenopausal age by optimizing management and postoperative rehabilitation. Materials and methods. A prospective study of 60 Human papillomavirus (HPV) positive women of perimenopausal age with morphologically verified recurrent CIN II was carried out. Patients of the Group I (n=30) after radiowave conization of the cervix transvaginally used suppositories with ingredients of natural origin - centella asiatica, calendula, aloe, tea tree essential oil, hyaluronic acid, orally - a blend of extracts of herbs of Deschampsia caespitosa L., Calamagrostis epigejos, Echinacea purpurea. Patients of the Group II (n=30) received vaginal suppositories with methyluracil in the postoperative period. Results. Cervical reepithelialization after the use of optimized management tactics was diagnosed in 100% of women, which occurred 1.3 times faster than in patients receiving traditional treatment. After 12 months from the start of treatment, the absence of multiple HPV infection and clinically significant viral load were determined, total elimination of the HPV in 96.7% of patients who received an optimized treatment complex. Conclusions. Radiowave therapy in combination with a blend of plant extracts and ingredients of natural origin for topical use has anti-inflammatory, immunomodulatory, antiviral, and reparative effects, prevents the occurrence of postoperative complications, has adequate safety and tolerability. The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent was obtained from all patients. No conflict of interests was declared by the authors.