Fibroblast exosomes promote wound healing and improve the quality of healed skin via miR-29a-3p-mediated KEAP1/Nrf2 pathway activation
Fibroblast exosomes alleviate oxidative damage by modulating the KEAP1/Nrf2 pathway through miR-29a-3p and enhancing epidermal stem cell function. These exosomes exhibit remarkable therapeutic potential in accelerating wound healing and improving healing quality under both normal and diabetic conditions, offering a robust foundation for innovative therapeutic strategies.
Authors
- Jiacai Yang (ORCID: https://orcid.org/0000-0002-3543-9238)
- Gaoxing Luo
- Canhua Huang (ORCID: https://orcid.org/0000-0003-2247-7750)
- Lingfeng Yan (ORCID: https://orcid.org/0009-0002-4997-0780)
- Hong Wang (ORCID: https://orcid.org/0000-0003-0477-2908)
- Jue Wang (ORCID: https://orcid.org/0000-0002-9948-4783)
- Xiaorong Zhang (ORCID: https://orcid.org/0000-0003-0277-5574)
- Xiaohong Hu (ORCID: https://orcid.org/0000-0002-7196-737X)
- Xin Cai
- Ruoyu Shang (ORCID: https://orcid.org/0000-0001-5353-9702)
- Wenjing Yin (ORCID: https://orcid.org/0009-0009-2613-633X)
- Yong Huang (ORCID: https://orcid.org/0000-0002-6985-0105)
- Dejiang Fan (ORCID: https://orcid.org/0009-0002-4417-4283)
- Weifeng He
Institutions
- Army Medical University (CN)
- Sichuan University (CN)
- Daping Hospital (CN)
- State Key Laboratory of Biotherapy
Publication Details
- Journal
- Burns & Trauma
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/burnst/tkaf035
- Citations
- 2
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.05