QT Interval Prolongation in TB/HIV Coinfection: Drug Interactions, Risks, and Clinical Recommendations

TB/HIV coinfection is associated with a high risk of QT interval prolongation during multi-drug therapy, increasing the likelihood of severe cardiotoxic complications. This article analyzes the mechanisms of drug-induced QT interval prolongation in coinfected patients, including Bedaquiline, Moxifloxacin, Clofazeminum and antiretroviral drugs, and discusses strategies to prevent arrhythmias. Recommendations include QT interval monitoring, electrolyte balance control, and the use of genetic testing for a personalized therapeutic approach. This study aims to improve the safety and efficacy of treatment, contributing to reduced mortality among TB/HIV coinfected patients.