Formulation And Evaluation Of The Dolutegravir Nanocrystals

Drugs with low water solubility may be delivered more easily with the help of nanocrystals. The use of low energy anti-solvent precipitation to create nanocrystals has been examined in this work, for the anti-retroviral medication dolutegravir, which is essentially poorly insoluble in water, stable nanocrystals with consistent particle sizes were created. Due to its limited water solubility, dolutegravir, a powerful HIV integrase inhibitor, has problems that impact both its bioavailability and effectiveness. The purpose of this study was to improve the solubility and bioavailability of dolutegravir by creating oral nanocrystal tablets. A bottom-up method was used to create the nanocrystals, and appropriate excipients were used to stabilize them. When compared to the pure medication, the optimized nanocrystal formulation showed better solubility and dissolution rates.The nanocrystal powder was used to produce oral tablets, which were then tested for pharmacokinetic profile and effectiveness in HIV-infected cells. The results demonstrated that the oral nanocrystal Dolutegravir tablets had better bioavailability and efficacy. This innovative formulation strategy has the potential to enhance HIV patients' treatment results.