Idiopathic Cervical Transverse Myelitis Presenting Predominantly With Lower Limb Weakness and Autonomic Dysfunction: A Report of a Rare Case

Transverse myelitis (TM) is a rare neuroinflammatory disorder that can lead to significant morbidity if not promptly diagnosed and treated. We report the case of a 40-year-old female who presented with progressive bilateral lower limb weakness and urinary incontinence over a two-month period. Neurological examination revealed upper motor neuron signs and a defined sensory level, raising suspicion of a spinal cord pathology. MRI of the cervicothoracic spine showed T2- and Short Tau Inversion Recovery (STIR)-weighted hyperintense lesions extending from C3 to C6, with mild cord expansion, suggestive of an inflammatory demyelinating process consistent with transverse myelitis. An extensive laboratory evaluation was unremarkable, and differential diagnoses such as multiple sclerosis, neuromyelitis optica, and sarcoidosis were excluded. Cerebrospinal fluid (CSF) analysis was not performed, representing a diagnostic limitation. With no identifiable infectious or autoimmune etiology, a diagnosis of idiopathic cervical transverse myelitis was made. The patient received high-dose intravenous corticosteroids followed by structured physiotherapy, resulting in marked clinical improvement within one week. This case underscores the importance of early recognition and intervention in atypical TM presentations, especially those involving the cervical spine, and demonstrates the potential for favorable outcomes with timely, individualized treatment.

Authors

Institutions

Publication Details

Journal
Cureus
Published
2025-05-17
DOI
https://doi.org/10.7759/cureus.84286
Primary Topic
Inflammatory Myopathies and Dermatomyositis
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Idiopathic Cervical Transverse Myelitis Presenting Predominantly With Lower Limb Weakness and Autonomic Dysfunction: A Report of a Rare Case

Farhan Akbar, M. Zamir, Umer Farooq, Aamir Bilal
Cureus
Inflammatory Myopathies and Dermatomyositis
article

Idiopathic Cervical Transverse Myelitis Presenting Predominantly With Lower Limb Weakness and Autonomic Dysfunction: A Report of a Rare Case

Farhan Akbar, M. Zamir, Umer Farooq, Aamir Bilal
article en

Abstract

Transverse myelitis (TM) is a rare neuroinflammatory disorder that can lead to significant morbidity if not promptly diagnosed and treated. We report the case of a 40-year-old female who presented with progressive bilateral lower limb weakness and urinary incontinence over a two-month period. Neurological examination revealed upper motor neuron signs and a defined sensory level, raising suspicion of a spinal cord pathology. MRI of the cervicothoracic spine showed T2- and Short Tau Inversion Recovery (STIR)-weighted hyperintense lesions extending from C3 to C6, with mild cord expansion, suggestive of an inflammatory demyelinating process consistent with transverse myelitis. An extensive laboratory evaluation was unremarkable, and differential diagnoses such as multiple sclerosis, neuromyelitis optica, and sarcoidosis were excluded. Cerebrospinal fluid (CSF) analysis was not performed, representing a diagnostic limitation. With no identifiable infectious or autoimmune etiology, a diagnosis of idiopathic cervical transverse myelitis was made. The patient received high-dose intravenous corticosteroids followed by structured physiotherapy, resulting in marked clinical improvement within one week. This case underscores the importance of early recognition and intervention in atypical TM presentations, especially those involving the cervical spine, and demonstrates the potential for favorable outcomes with timely, individualized treatment.

CureusVol. 17(5)
Nishtar Medical College and Hospital (PK), Benazir Bhutto Hospital (PK), Foundation University Medical College (PK)
Openalex Percentile: Top 84%
Inflammatory Myopathies and Dermatomyositis
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.