Co-occurrence of DNET and Hodgkin's Lymphoma in a patient with Noonan syndrome and mutation in the PTPN11 gene
This case underscores the complex relationship between NS and tumor development, reinforcing the importance of individualized surveillance strategies, particularly in patients undergoing rhGH therapy. Further studies are needed to clarify the oncogenic potential of specific NS-associated mutations and to establish evidence-based guidelines for cancer surveillance in these patients.
Authors
- Flávio Augusto Vercillo Luisi (ORCID: https://orcid.org/0000-0001-9197-2494)
- Nasjla Saba da Silva
- Alexsandra C. Malaquias (ORCID: https://orcid.org/0000-0003-1514-0244)
- Angela Maria Spinola‐Castro (ORCID: https://orcid.org/0000-0003-1974-0925)
- Adriana Aparecida Siviero‐Miachon (ORCID: https://orcid.org/0000-0002-3001-0184)
- Frederico Adolfo Benevides Silva (ORCID: https://orcid.org/0000-0001-9817-5949)
- Alexander A.L. Jorge (ORCID: https://orcid.org/0000-0003-2567-7360)
- Andréa Maria Cappellano (ORCID: https://orcid.org/0000-0002-3818-8876)
- Caroline Rosa Pellicciari
Institutions
- Irmandade da Santa Casa de Misericórdia de São Paulo (BR)
- Fundação de Apoio à Universidade Federal de São Paulo (BR)
- Support group for adolescents and children with cancer (BR)
- Faculdade de Ciências Médicas da Santa Casa de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Hormone Research in Paediatrics
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1159/000546262
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.00