Palladium(II)-Catalyzed Desymmetrization of 2-Alkynylbenzoate-Tethered Cyclohexadienones for the Synthesis of Polycyclic Compounds
Pd-catalyzed cascade cyclization of 2-alkynylbenzoate-tethered cyclohexadienone was developed for the single step synthesis of isocoumarin-fused dihydrochromenones. This highly atom economical method proceeds via 6-<i>endo-dig</i> cyclization of <i>tert</i>-butyl benzoate with a tethered alkyne. By modulating the reaction solvent and metal catalyst, the methodology was diverted for the purposeful synthesis of either of the <i>E/Z</i> tetra-substituted alkenes.
Authors
- Gamidi Rama Krishna (ORCID: https://orcid.org/0000-0001-5313-7746)
- Kumar Vanka (ORCID: https://orcid.org/0000-0001-7301-7573)
- Archana Rai (ORCID: https://orcid.org/0000-0002-2102-1957)
- Priyam Bajpai (ORCID: https://orcid.org/0000-0002-6933-4741)
- Utpal Das (ORCID: https://orcid.org/0000-0002-4580-8957)
Institutions
- National Chemical Laboratory (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1021/acs.orglett.5c01396
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Council of Scientific and Industrial Research, India
- Science and Engineering Research Board