Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation
cGAS signalling contributes to pathogenic inflammatory myofibroblast phenotypes in SSc‑ILD. Inhibiting cGAS or its downstream effectors represents a novel therapeutic approach.
Authors
- John Varga (ORCID: https://orcid.org/0000-0001-8400-687X)
- Taylor Pivarnik
- Maor Sauler (ORCID: https://orcid.org/0000-0001-5240-7978)
- Ying Sun
- Erica L. Herzog (ORCID: https://orcid.org/0000-0002-7508-8575)
- C. Hyun Ryu (ORCID: https://orcid.org/0000-0001-8656-3581)
- José L. Gómez (ORCID: https://orcid.org/0000-0002-6521-6318)
- Huanxing Sun (ORCID: https://orcid.org/0000-0003-2397-4652)
- Buqu Hu (ORCID: https://orcid.org/0000-0001-7233-987X)
- William D. Odell (ORCID: https://orcid.org/0000-0003-0749-363X)
- Monique Hinchcliff (ORCID: https://orcid.org/0000-0002-8652-9890)
- Alexander Ghincea (ORCID: https://orcid.org/0000-0001-7404-9921)
- Genta Ishikawa (ORCID: https://orcid.org/0000-0002-8882-8288)
- Anjali Walia (ORCID: https://orcid.org/0000-0003-1669-5532)
- J. Zielonka (ORCID: https://orcid.org/0000-0003-2444-5277)
- Carol Feghali‐Bostwick (ORCID: https://orcid.org/0000-0002-6750-6407)
- Baran Ilayda Gunes
- John McGovern (ORCID: https://orcid.org/0009-0007-1310-3999)
- Sheeline Yu
- Shuai Shao (ORCID: https://orcid.org/0000-0003-0699-1864)
- Sophia Kujawski
- Chris Lee (ORCID: https://orcid.org/0009-0008-8285-4523)
- Shifa Gandhi
- Samuel Woo
- Xue Yan Peng
- Tina Saber
- S. Perez
Institutions
- Medical University of South Carolina (US)
- University of Michigan (US)
- Herzog College (IL)
- Yale University (US)
- ENT and Allergy (US)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1183/13993003.01564-2024
- Citations
- 4
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- Boehringer Ingelheim
- Pulmonary Fibrosis Foundation
- National Institutes of Health