Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation

cGAS signalling contributes to pathogenic inflammatory myofibroblast phenotypes in SSc‑ILD. Inhibiting cGAS or its downstream effectors represents a novel therapeutic approach.

Authors

Institutions

Publication Details

Journal
European Respiratory Journal
Published
2025-05-15
DOI
https://doi.org/10.1183/13993003.01564-2024
Citations
4
Primary Topic
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Type
article
Field-Weighted Citation Impact
6.07

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation

John Varga, Taylor Pivarnik, Maor Sauler, Ying Sun et al.
4 citations
European Respiratory Journal
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
6.07
article

Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation

John Varga, Taylor Pivarnik, Maor Sauler, Ying Sun, Erica L. Herzog, C. Hyun Ryu, José L. Gómez, Huanxing Sun, Buqu Hu, William D. Odell, Monique Hinchcliff, Alexander Ghincea, Genta Ishikawa, Anjali Walia, J. Zielonka, Carol Feghali‐Bostwick, Baran Ilayda Gunes, John McGovern, Sheeline Yu, Shuai Shao, Sophia Kujawski, Chris Lee, Shifa Gandhi, Samuel Woo, Xue Yan Peng, Tina Saber, S. Perez
article en
4 citations

Abstract

cGAS signalling contributes to pathogenic inflammatory myofibroblast phenotypes in SSc‑ILD. Inhibiting cGAS or its downstream effectors represents a novel therapeutic approach.

European Respiratory JournalVol. 66(2)
Medical University of South Carolina (US), University of Michigan (US), Herzog College (IL), Yale University (US), ENT and Allergy (US)
Boehringer Ingelheim, Pulmonary Fibrosis Foundation, National Institutes of Health
Openalex Percentile: Top 4%
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
6.07
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.