From North Asia to South America: Tracing the longest human migration through genomic sequencing
Genome sequencing of 1537 individuals from 139 ethnic groups reveals the genetic characteristics of understudied populations in North Asia and South America. Our analysis demonstrates that West Siberian ancestry, represented by the Kets and Nenets, contributed to the genetic ancestry of most Siberian populations. West Beringians, including the Koryaks, Inuit, and Luoravetlans, exhibit genetic adaptation to Arctic climate, including medically relevant variants. In South America, early migrants split into four groups-Amazonians, Andeans, Chaco Amerindians, and Patagonians-~13,900 years ago. Their longest migration led to population decline, whereas settlement in South America's diverse environments caused instant spatial isolation, reducing genetic and immunogenic diversity. These findings highlight how population history and environmental pressures shaped the genetic architecture of human populations across North Asia and South America.
Authors
- А. А. Зарубин (ORCID: https://orcid.org/0000-0001-6568-6339)
- Е. Р. Еремина (ORCID: https://orcid.org/0000-0002-5722-7586)
- Nurul Adilah Binte Ramli (ORCID: https://orcid.org/0000-0003-0341-8624)
- Shigeki Nakagome (ORCID: https://orcid.org/0000-0001-9613-975X)
- Aakrosh Ratan (ORCID: https://orcid.org/0000-0002-0782-3056)
- О. В. Штыгашева (ORCID: https://orcid.org/0000-0002-5522-1148)
- Soo Guek Ng
- Э. В. Каспаров (ORCID: https://orcid.org/0000-0002-5988-1688)
- See Ting Leong
- Н. А. Колесников (ORCID: https://orcid.org/0000-0001-8855-577X)
- Amit Gourav Ghosh (ORCID: https://orcid.org/0000-0002-5991-8110)
- Atsushi Tajima (ORCID: https://orcid.org/0000-0001-6808-5491)
- Niall P. Cooke (ORCID: https://orcid.org/0000-0002-1265-1148)
- Cassie E. Heinle
- Ian McGonigle (ORCID: https://orcid.org/0000-0003-0837-080X)
- Justine Dacanay (ORCID: https://orcid.org/0000-0001-5823-2013)
- Changsook Park
- Deepa Panicker
- I. Yu. Khitrinskaya (ORCID: https://orcid.org/0000-0002-6684-6020)
- Elena S. Gusareva (ORCID: https://orcid.org/0000-0001-9019-8097)
- Choou Fook Lee
- Inaho Danjoh
- Seik‐Soon Khor (ORCID: https://orcid.org/0000-0002-6809-4731)
- Sergey Tereshchenko (ORCID: https://orcid.org/0000-0002-1605-7859)
- Sachin R. Lohar
- Cláudio M. Bravi (ORCID: https://orcid.org/0000-0002-2499-4471)
- Yukio Nakamura (ORCID: https://orcid.org/0000-0001-6834-4123)
- Zhei Hwee Yap (ORCID: https://orcid.org/0000-0002-5137-3013)
- М. В. Голубенко (ORCID: https://orcid.org/0000-0002-7692-9954)
- V. N. Kharkov (ORCID: https://orcid.org/0000-0002-1679-2212)
- Nikita Moshkov (ORCID: https://orcid.org/0000-0002-5823-4884)
- Hie Lim Kim (ORCID: https://orcid.org/0000-0003-3080-9524)
- Tatiana V. Tatarinova (ORCID: https://orcid.org/0000-0003-1787-1112)
- Hideyuki Tanabe (ORCID: https://orcid.org/0000-0002-2411-1552)
- M. G. Swarovskaya (ORCID: https://orcid.org/0000-0002-5020-4971)
- Poh Nee Ang
- Namrata Kalsi
- Daniela I. Drautz‐Moses (ORCID: https://orcid.org/0000-0002-3739-0917)
- Andrey Marusin (ORCID: https://orcid.org/0000-0002-4642-7515)
- M. V. Smolnikova (ORCID: https://orcid.org/0000-0001-9984-2029)
- Andrés Moreno‐Estrada (ORCID: https://orcid.org/0000-0001-8329-8292)
- Stephan C. Schuster (ORCID: https://orcid.org/0000-0001-9082-7527)
- Vadim Stepanov
- Yanqing Koh
- Katsushi Tokunaga
- Aitalina Sukhomyasova
- К. В. Вагайцева
- Magomed O. Razhabov
Institutions
- Kanazawa University (JP)
- National University of Ireland, Maynooth (IE)
- Nanyang Technological University (SG)
- Buryat State University (RU)
- Tohoku University (JP)
- Trinity College Dublin (IE)
- HUN-REN Szegedi Biológiai Kutatóközpont (HU)
- National Center for Global Health and Medicine (JP)
- RIKEN BioResource Research Center (JP)
- Tohoku Medical Megabank Organization (JP)
- Singapore Centre for Environmental Life Sciences Engineering (SG)
- University of Virginia (US)
- University of La Verne (US)
Publication Details
- Journal
- Science
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1126/science.adk5081
- Citations
- 11
- Primary Topic
- Forensic and Genetic Research
- Type
- article
- Field-Weighted Citation Impact
- 19.99