Diverse bat organoids provide pathophysiological models for zoonotic viruses
Bats are important reservoirs of zoonotic pathogens, but suitable model systems for comprehensively exploring host-pathogen interactions and assessing spillover risks remain limited. To address this gap, we developed a collection of bat organoid models spanning five species and four organ types. This multispecies, multiorgan organoid panel showed species- and tissue-specific replication patterns for several viruses, offering robust pathophysiological models for studying respiratory, renal, and enteric zoonotic viruses. Using this platform, we successfully isolated and characterized bat-borne mammalian orthoreoviruses and paramyxoviruses, demonstrating the utility of these organoid panels for virome surveillance. Furthermore, we successfully tested known antiviral drugs for their efficacy against bat virus isolates.
Authors
- Bon‐Kyoung Koo (ORCID: https://orcid.org/0000-0002-4134-8033)
- Richard J. Webby (ORCID: https://orcid.org/0000-0002-4397-7132)
- Dongbin Park (ORCID: https://orcid.org/0000-0001-5289-1034)
- Jaemoo Kim (ORCID: https://orcid.org/0009-0003-4216-8397)
- Bo‐Young Jeon (ORCID: https://orcid.org/0000-0002-4314-216X)
- Seo-Young Heo
- Rare Rollon (ORCID: https://orcid.org/0000-0002-8428-1713)
- Ho Bin Jang (ORCID: https://orcid.org/0000-0003-1316-316X)
- Juryeon Gil (ORCID: https://orcid.org/0000-0002-9415-0688)
- Jae‐Woo Ahn (ORCID: https://orcid.org/0000-0002-2706-5010)
- Seung‐Gyu Jang (ORCID: https://orcid.org/0000-0001-9316-1652)
- Young Ki Choi (ORCID: https://orcid.org/0000-0002-0872-0147)
- Boyeong Jeong (ORCID: https://orcid.org/0009-0008-2541-0328)
- Jeongmin Ha (ORCID: https://orcid.org/0000-0001-7232-4192)
- K.‐S. Kim (ORCID: https://orcid.org/0009-0004-0508-4896)
- Ghazi Kayali (ORCID: https://orcid.org/0000-0002-5387-1622)
- Jeong Ho Choi
- Eun-Ha Kim (ORCID: https://orcid.org/0000-0003-1443-3416)
- Hyunjoon Kim (ORCID: https://orcid.org/0000-0002-0207-1190)
- Sujin Park (ORCID: https://orcid.org/0000-0002-1211-8394)
- Young‐Il Kim (ORCID: https://orcid.org/0000-0002-0145-7382)
- Yong-Ki Lee (ORCID: https://orcid.org/0000-0001-5976-3043)
- Ho Young Ji
- Se‐Mi Kim (ORCID: https://orcid.org/0000-0001-7932-1381)
- Woohyun Kwon (ORCID: https://orcid.org/0009-0006-9023-0273)
- Suhee Hwang (ORCID: https://orcid.org/0000-0002-1028-1323)
- Josea Carmel Lazarte
- Isaac Choi
Institutions
- Pohang University of Science and Technology (KR)
- St. Jude Children's Research Hospital (US)
- Chungbuk National University (KR)
- Yonsei University (KR)
- Institute for Basic Science (KR)
- Regenerative Medicine Institute (MX)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Science
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1126/science.adt1438
- Citations
- 13
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 18.15