Feasibility of Point-of-Care Urine Self-Testing to Measure Tenofovir Adherence and Predict Viral Suppression
This study is the first to demonstrate the feasibility of at-home adherence monitoring using a point-of-care urine assay for tenofovir (TFV). Undetectable TFV is strongly associated with lower viral suppression (odds ratio, 0.19, 95% CI, 0.10-0.34; <i>P</i> < .001), supporting a streamlined, effective approach for monitoring adherence between viral load assessments.
Authors
- Sabina Hirshfield (ORCID: https://orcid.org/0000-0002-2649-469X)
- Keith J. Horvath (ORCID: https://orcid.org/0000-0001-7569-2839)
- Matthew A. Spinelli (ORCID: https://orcid.org/0000-0001-6368-8664)
- Helmut H. Schmidt (ORCID: https://orcid.org/0009-0005-5478-2997)
- Christian Grov (ORCID: https://orcid.org/0000-0001-6871-3531)
- David V. Glidden (ORCID: https://orcid.org/0000-0001-5888-1419)
- Megan J. Heise (ORCID: https://orcid.org/0000-0001-6651-2381)
- Alexa B. D’Angelo (ORCID: https://orcid.org/0000-0001-5260-340X)
- Renata Buccheri (ORCID: https://orcid.org/0000-0002-3217-5898)
- Dustin T. Duncan (ORCID: https://orcid.org/0000-0001-8586-8711)
- Adam W. Carrico (ORCID: https://orcid.org/0000-0002-8146-5701)
- Tyler Martinson (ORCID: https://orcid.org/0000-0001-6750-3954)
- Mallory O. Johnson (ORCID: https://orcid.org/0000-0003-0480-2804)
- Renessa S. Williams (ORCID: https://orcid.org/0000-0003-4814-1534)
- Monica Gandhi (ORCID: https://orcid.org/0000-0001-6674-5388)
- Kevin Sassaman (ORCID: https://orcid.org/0009-0003-4636-4045)
Institutions
- The Graduate Center, CUNY (US)
- State University of New York (US)
- University of Miami (US)
- City University of New York (US)
- University of California, San Francisco (US)
- SUNY Downstate Health Sciences University (US)
- Florida International University (US)
- San Diego State University (US)
- Pacific Research Institute (US)
- University of California System (US)
- Vitalant (US)
- Global Solutions for Infectious Diseases (US)
- University of San Francisco (US)
- Columbia University (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1093/ofid/ofaf300
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health