Unveiling metabolic pathways in the hyperglycemic bone: bioenergetic and proteomic analysis of the bone tissue exposed to acute and chronic high glucose
Chronic high glucose exposure disrupted bone bioenergetics, induced mitochondrial dysfunction, and compromised bone structural integrity, emphasizing the metabolic impact of hyperglycemia in diabetic bone disease.
Authors
- Pedro Sousa Gomes (ORCID: https://orcid.org/0000-0001-5365-2123)
- Mariana P. Monteiro (ORCID: https://orcid.org/0000-0002-0662-1831)
- Raquel L. Bernardino (ORCID: https://orcid.org/0000-0002-1941-6634)
- Rita Araújo (ORCID: https://orcid.org/0000-0002-6451-9990)
Institutions
- Universidade do Porto (PT)
- Rede de Química e Tecnologia (PT)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1186/s10020-025-01251-0
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Ministério da Ciência, Tecnologia e Ensino Superior
- Fundação para a Ciência e a Tecnologia