Alternative mRNA splicing in anthracycline-induced cardiomyopathy – a COG-ALTE03N1 report
We identified specific alternative splicing events in anthracycline-exposed childhood cancer survivors with and without cardiomyopathy. Our findings suggest that differential alternative splicing events can provide additional insight into the peripheral blood transcriptomic landscape of anthracycline-induced cardiomyopathy.
Authors
- Liting Zhou (ORCID: https://orcid.org/0000-0003-1852-4745)
- Lindsey Hageman (ORCID: https://orcid.org/0009-0009-2396-5634)
- Frank M. Balis (ORCID: https://orcid.org/0000-0002-8117-6926)
- Changde Cheng (ORCID: https://orcid.org/0000-0002-2458-2522)
- Noha Sharafeldin (ORCID: https://orcid.org/0000-0001-8835-8899)
- Patrick J. Trainor (ORCID: https://orcid.org/0000-0002-3012-9716)
- Saro H. Armenian (ORCID: https://orcid.org/0000-0003-2604-8603)
- Smita Bhatia (ORCID: https://orcid.org/0000-0002-7755-5683)
- Jill P. Ginsberg (ORCID: https://orcid.org/0000-0001-7412-2017)
- Frank G. Keller (ORCID: https://orcid.org/0000-0001-6165-5666)
- David K. Crossman (ORCID: https://orcid.org/0000-0002-0981-169X)
- Wendy Landier (ORCID: https://orcid.org/0000-0003-3319-5652)
- Purnima Singh (ORCID: https://orcid.org/0000-0002-4968-7398)
- Joseph P. Neglia (ORCID: https://orcid.org/0000-0002-5525-0598)
- Douglas S. Hawkins (ORCID: https://orcid.org/0000-0003-3602-1375)
- Melissa M. Hudson (ORCID: https://orcid.org/0000-0001-6984-2407)
- Xuexia Wang (ORCID: https://orcid.org/0000-0002-0613-2608)
Institutions
- University of Minnesota (US)
- St. Jude Children's Research Hospital (US)
- Children's Hospital of Philadelphia (US)
- Emory University (US)
- Florida International University (US)
- University of Alabama at Birmingham (US)
- Seattle Children's Hospital (US)
- City of Hope (US)
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1186/s40959-025-00345-2
- Citations
- 2
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- V Foundation for Cancer Research
- Leukemia and Lymphoma Society
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Mental Health
- National Institute on Drug Abuse
- National Human Genome Research Institute
- NIH Office of the Director
- National Cancer Institute
- National Institute of Neurological Disorders and Stroke
- Common Fund