BRCA2 Mitigates PARP1 Retention at DNA Repair Sites to Stabilize RAD51

Major Finding: BRCA2 protects RAD51 stability at DNA repair sites by hindering the retention of PARP1 on DNA.Concept: RAD51-destabilizing PARP1:DNA binding is enhanced in BRCA2-deficient cells following PARP inhibition. Impact: This study provides a mechanism for heightened response to PARP inhibition in BRCA2-mutant cancers.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-042
Primary Topic
DNA Repair Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

BRCA2 Mitigates PARP1 Retention at DNA Repair Sites to Stabilize RAD51

Cancer Discovery
DNA Repair Mechanisms
article

BRCA2 Mitigates PARP1 Retention at DNA Repair Sites to Stabilize RAD51

article en

Abstract

Major Finding: BRCA2 protects RAD51 stability at DNA repair sites by hindering the retention of PARP1 on DNA.Concept: RAD51-destabilizing PARP1:DNA binding is enhanced in BRCA2-deficient cells following PARP inhibition. Impact: This study provides a mechanism for heightened response to PARP inhibition in BRCA2-mutant cancers.

Cancer Discovery
Openalex Percentile: Top 90%
DNA Repair Mechanisms
DOISourceOpenAlex
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BRCA2 Mitigates PARP1 Retention at DNA Repair Sites to Stabilize RAD51 · Cancer Discovery (2025) | TGRS Research Map | TGRS