Complementary Analysis of Local and Systemic Effects of Dupilumab in Paediatric AD Using Tape Strips and Serum
Our findings provide insight into the distinct local and systemic proteomic changes in response to dupilumab treatment in paediatric AD patients. These findings underscore the complementary roles of tape strips and serum in profiling immune and epidermal barrier proteins, highlighting the utility of minimally invasive tape stripping for monitoring proteomic responses to targeted therapies in paediatric AD.
Authors
- Marjolein S. de Bruin-Weller (ORCID: https://orcid.org/0000-0002-1249-6993)
- Edward F. Knol (ORCID: https://orcid.org/0000-0001-7368-9820)
- Femke van Wijk (ORCID: https://orcid.org/0000-0001-8343-1356)
- Lisa P. van der Rijst (ORCID: https://orcid.org/0000-0002-5865-8986)
- Marlies de Graaf (ORCID: https://orcid.org/0000-0001-9004-5111)
- Nicolaas P. A. Zuithoff (ORCID: https://orcid.org/0000-0002-4441-1448)
- Constance F. den Hartog Jager
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Wilhelmina Children's Hospital (NL)
Publication Details
- Journal
- Clinical & Experimental Allergy
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1111/cea.70082
- Citations
- 4
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 8.02
Funders
- Eli Lilly and Company
- Pfizer
- Sanofi
- Regeneron Pharmaceuticals
- LEO Pharma