An Automated User-friendly Software for Fast Computation of Blood Flow Velocity From Coronary Angiographic Images
Thrombolysis in myocardial infarction frame count enables assessment of coronary flow but cannot measure coronary flow velocity (CFV), which is needed to examine microvascular function. To overcome this limitation, we introduce a semi-automated software for fast CFV computation using contrast bolus tracking techniques in angiography and compare its performance against experts. The study included patients undergoing coronary angiography. Two experts measured the CFV using the number of frames, segment length, and frame rate. Measurements were repeated for shorter segments and different projections, and their estimations were compared with the software. In total, 123 patients (152 vessels) were included. The software had excellent reproducibility in measuring CFV (intraclass correlation coefficient (ICC) = .995), which was superior to experts (ICC = .946) and provided similar estimations irrespective of the segment length (ICC = .992); conversely, the experts overestimated CFV in short segments. The reproducibility of the experts and the software was moderate when comparing CFV measurements in different projections (first expert vs software ICC = .807, second expert vs software ICC = .790, first expert vs second expert ICC = .885). The software provides reproducible CFV estimations that are close to experts' estimations. Further validation against wire-based functional techniques is needed to examine its potential in assessing microvascular function.
Authors
- Medeni Karaduman (ORCID: https://orcid.org/0000-0002-6080-6335)
- Nathan Angelo Lecaros Yap (ORCID: https://orcid.org/0000-0001-6294-5796)
- Ryo Torii (ORCID: https://orcid.org/0000-0001-9479-8719)
- Emrah Erdoğan (ORCID: https://orcid.org/0000-0003-2329-6310)
- İbrahi̇m Hali̇l Tanboğa (ORCID: https://orcid.org/0000-0003-4546-9227)
- Vincenzo Tufaro (ORCID: https://orcid.org/0000-0003-3761-528X)
- Christos V. Bourantas (ORCID: https://orcid.org/0000-0001-5319-1064)
- Andreas Baumbach (ORCID: https://orcid.org/0000-0001-7707-2254)
- Zaid A. Abdulelah (ORCID: https://orcid.org/0000-0002-1952-4627)
- Anthony Mathur (ORCID: https://orcid.org/0000-0001-7941-9653)
- Patrick W. Serruys (ORCID: https://orcid.org/0000-0002-9636-1104)
- Alun David Hughes (ORCID: https://orcid.org/0000-0001-5432-5271)
- Xingwei He (ORCID: https://orcid.org/0000-0002-1438-8355)
- Bon‐Kwon Koo (ORCID: https://orcid.org/0000-0002-8188-3348)
- Grigoris V. Karamasis (ORCID: https://orcid.org/0000-0002-4560-7629)
- Retesh Bajaj (ORCID: https://orcid.org/0000-0001-7424-0419)
- Tingquan Zhou (ORCID: https://orcid.org/0000-0002-7636-7453)
- Murat Çap (ORCID: https://orcid.org/0000-0003-1164-2124)
- Roby Rakhit (ORCID: https://orcid.org/0000-0002-0108-8169)
- Ameer Khan
- Jean-Paul Aben
Institutions
- Van Yüzüncü Yıl Üniversitesi (TR)
- Ministry of Health (TR)
- Queen Mary University of London (GB)
- Royal Free London NHS Foundation Trust (GB)
- Barts Health NHS Trust (GB)
- Seoul National University Hospital (KR)
- İstanbul Nişantaşı Üniversitesi (TR)
- Essex Cardiothoracic Centre (GB)
- Sağlık Bilimleri Üniversitesi (TR)
- Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi (TR)
- Shanghai Sixth People's Hospital (CN)
- William Harvey Research Institute (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Angiology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1177/00033197251338474
- Citations
- 3
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Türk Kardiyoloji Derneği