Thermoregulation in multiple sclerosis: Hypothalamus irregulation, cortisol, yawning, fatigue and the Thompson cortisol hypothesis

Multiple Sclerosis (MS) is a degenerative disease with symptoms that include irregulation of body temperature, fatigue, depression and often excessive yawning. Fatigue is an ongoing issue for many people with MS and there is little understood about the mechanisms involved in regulating body temperature in MS after activity. Measuring and monitoring fatigue and body temperature has been reported in healthy subjects but no reports to date have considered thermoregulation monitoring using E-textile specialist wearable garments in MS. Discussion of the thermoregulatory mechanism involved in MS is offered together with recommendations for assisting people with MS in temperature control following fatigue and during activity. Keywords: Cortisol; Diagnosis; E-textiles; Fatigue; Hypothalamus; Multiple sclerosis; Neurology; Thermoregulation; Thompson cortisol hypothesis; Yawning