Predicting memory decline from left temporal lobe epilepsy surgery using preoperative fMRI: a multicenter study
We demonstrate that models incorporating fMRI language LIs from a semantic decision task trained to predict verbal memory decline after left temporal lobe surgery provide meaningful information to help inform patients of the risk associated with left temporal lobe surgery and are practical to implement in different hospital settings. This confirms previous limited evidence that fMRI-based preoperative language protocols can be used to predict verbal episodic memory outcome after left temporal lobe epilepsy surgery.
Authors
- Jeffrey R. Binder (ORCID: https://orcid.org/0000-0002-2233-5640)
- Chad Carlson
- Sara B. Pillay (ORCID: https://orcid.org/0000-0003-1986-061X)
- Jerzy P. Szaflarski (ORCID: https://orcid.org/0000-0002-5936-6627)
- Manoj Raghavan (ORCID: https://orcid.org/0000-0003-0227-3160)
- Mark J. Lowe (ORCID: https://orcid.org/0000-0002-7022-8436)
- Wade M. Mueller
- Susan Y. Bookheimer (ORCID: https://orcid.org/0000-0002-3417-5891)
- Alexander I. Helfand
- Daniel L. Drane (ORCID: https://orcid.org/0000-0001-8747-672X)
- Victoria L. Morgan (ORCID: https://orcid.org/0000-0001-8263-2324)
- Thomas J. Grabowski (ORCID: https://orcid.org/0000-0002-7425-6610)
- Robyn M. Busch (ORCID: https://orcid.org/0000-0002-5442-4912)
- Madalina E. Tivarus (ORCID: https://orcid.org/0000-0001-7481-5913)
- Leonardo Bonilha (ORCID: https://orcid.org/0000-0002-6153-8942)
- Lisa L. Conant (ORCID: https://orcid.org/0000-0002-5050-3437)
- Jennifer Vannest (ORCID: https://orcid.org/0000-0001-7888-0245)
- Jane B. Allendorfer (ORCID: https://orcid.org/0000-0001-6888-9000)
- William L. Gross
- Colin Humphries (ORCID: https://orcid.org/0000-0002-5131-8743)
- Sara J. Swanson
- Monica Jacobs (ORCID: https://orcid.org/0000-0002-3938-4764)
Institutions
- Cleveland Clinic (US)
- Emory University (US)
- Medical University of South Carolina (US)
- Henry Ford Health System (US)
- University of California, Los Angeles (US)
- University of Washington (US)
- Medical College of Wisconsin (US)
- University of Alabama at Birmingham (US)
- University of Rochester (US)
- University of Cincinnati (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- NeuroImage Clinical
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.nicl.2025.103804
- Citations
- 2
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Institute of Neurological Disorders and Stroke
- National Center for Advancing Translational Sciences