Promotion of Melanoma Progression through MCM4-Induced Immune Suppression and Polarization of Macrophages by Carcinogenic Exosomes
Exosomes secreted by MCM4-overexpressed melanocytes could stimulate their proliferation, migration, and invasion abilities. MCM4 promoted M2 polarization of macrophages, indicating its crucial role in tumor microenvironment formation and thereby facilitating tumor development.
Authors
- Sirong Liu (ORCID: https://orcid.org/0009-0001-0523-6317)
- Deni Kang
- Ronghua Yang (ORCID: https://orcid.org/0000-0001-7873-6892)
- Xuewei Zhang (ORCID: https://orcid.org/0000-0003-4516-575X)
Institutions
- Guangzhou First People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Current Cancer Drug Targets
- Published
- 2025-05-14
- DOI
- https://doi.org/10.2174/0115680096357750250507073948
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00