A Case Series Study of Nasopharyngeal Carcinoma Cases with Uncommon Presentations

Nasopharyngeal carcinoma (NPC) is a malignancy of nasopharynx with a distinct geographical and epidemiological distribution mainly seen in Southeast Part of China and North Eastern region of India, commonly etiological factors of Epstein-Barr virus (EBV) infection and certain food habits also noted. patients presenting with atypical presentations which leads to delay and dilemma in diagnosis of patients of NPC. While typical presentations include bilateral jugular lymphadenopathy, nasal obstruction, and epistaxis leads to easy diagnose and rare and atypical manifestations can pose diagnostic challenges, leading to delays in diagnosis and treatment. This case series study highlights unusual presentations of NPC, including paraneoplastic syndromes, bilateral posterior triangle group of lymph nodes, cranial nerve palsies, and metastatic patterns, both local and distant, that deviate from the normal presentations. By examining these cases, we aim to raise awareness among clinicians about the diverse clinical spectrum of NPC, emphasizing the importance of maintaining a high index of suspicion in atypical scenarios. Early diagnosis and intervention are vital steps to improve outcomes in these rare presentations. Key words: NPC, Nasopharynx, carcinoma, rare cases, diagnostic challenges, uncommon presentations, early diagnosis