The Relationship between Glucosamine and Fish Oil and the Risk of Urolithiasis: A Large Prospective Cohort Study

目的：探讨葡萄糖胺和鱼油与尿石症风险的关系，旨在为预防尿石症提供饮食指导。方法：通过英国生物银行从英国各地招募了约50万名年龄在40~69岁之间的参与者，通过下载国外公开数据库数据用于本研究。结果：葡萄糖胺使用者的尿石症风险显著降低(HR = 0.77, 95% CI: 0.72~0.83, P P = 0.0006)。联合使用鱼油和葡萄糖胺的参与者表现出最强的保护效应。与非使用者相比，联合使用者的尿石症风险显著降低(HR = 0.83, 95% CI: 0.75~0.90, P Objective: To investigate the association between glucosamine and fish oil with the risk of urolithiasis, and to provide dietary guidance for the prevention of urolithiasis. Methods: Approximately 500,000 participants aged 40~69 were recruited from across the United Kingdom through the UK Biobank, and data from publicly available international databases were downloaded for this study. Results: Glucosamine users exhibited a significantly reduced risk of urolithiasis (HR = 0.77, 95% CI: 0.72–0.83, P P = 0.0006). Participants who used both fish oil and glucosamine showed the strongest protective effect. Compared to non-users, the combined use of these supplements was associated with a significantly lower risk of urolithiasis (HR = 0.83, 95% CI: 0.75~0.90, P < 0.0001). Conclusion: The combined use of glucosamine and fish oil is associated with a reduced risk of urolithiasis.