Research Progress on Triglyceride Glucose Index and Adverse Prognosis in Patients with Coronary Heart Disease

冠状动脉粥样硬化性心脏病(CHD)作为一种心血管疾病，严重威胁着人类生命健康。而胰岛素抵抗(IR)，不仅导致糖尿病发生，也与冠心病的发生发展密切相关，研究两者之间的关系，对冠心病的预防、诊治及随诊至关重要。胰岛素抵抗(IR)的金标准是高胰岛素正葡萄糖钳夹试验，由于其操作复杂、费时等原因限制了在临床的应用。空腹甘油三酯和葡萄糖浓度计算所得的甘油三酯葡萄糖指数(triglycerideglucose index，TyG指数)与葡萄糖钳夹技术有很好的相关性。故临床工作中常用TyG指数评价受试者的胰岛素抵抗程度。近年来，有许多研究证实了TyG与冠心病患者主要不良心血管事件(MACEs)的关系。本研究旨在总结近年来关于TyG与冠心病患者MACEs的研究进展，为冠心病患者冠脉病变严重程度的风险评估提供参考依据，对冠心病患者进行风险分层和针对性干预，延缓疾病进展、节约医疗资源、减轻个人经济负担。Coronary atherosclerotic heart disease (CHD), as a cardiovascular disease, seriously threatens human life and health. Insulin resistance (IR) not only leads to the occurrence of diabetes, but is also closely related to the occurrence and development of coronary heart disease, and studying the relationship between the two is very important for the prevention, diagnosis and treatment of coronary heart disease. The gold standard for insulin resistance (IR) is the hyperinsulinemic euglucose clamp test, which limits its clinical application due to its complex and time-consuming operation. The triglyceride glucose index (TyG index) calculated from fasting triglycerides and glucose concentrations had a good correlation with glucose clamping techniques. Therefore, the TyG index is commonly used in clinical work to evaluate the degree of insulin resistance of subjects. In recent years, a number of studies have confirmed the association between TyG and major adverse cardiovascular events (MACEs) in patients with coronary heart disease. The purpose of this study was to summarize the research progress on TyG and MACEs in patients with coronary heart disease in recent years, to provide a reference basis for the risk assessment of the severity of coronary artery disease in patients with coronary heart disease, to carry out risk stratification and targeted intervention for patients with coronary heart disease, to delay the progression of the disease, to save medical resources, and to reduce the financial burden of individuals.