Prognostic value of platelet indices and platelet-to-albumin ratioin assessing disease activity in crohn’s disease

Objective: to evaluate the prognostic value of selected platelet indices and platelet-to-albumin ratio in predicting disease activity in Crohn's disease. Subject and method: A cross-sectional descriptive study on 85 patients diagnosed with Crohn's disease at 108 Military Central Hospital from October 2021 to April 2025. Result: The mean age of participants was 37.14 ± 15.15 years; 63.5% were male. The age of disease onset was predominantly between 17 and 39 years (64.7%). The most common clinical symptoms were digestive disorders (89.4%) and abdominal pain (80%). The most frequent complications were fistula (32.9%) and stricture (23.5%). The platelet count (PLT), plateletcrit (PCT), and PLT/ALB ratio were significantly higher in the active Crohn’s disease group compared to the remission group (p < 0.01). These indices were also significantly correlated with the SES-CD score. PCT and the PLT/ALB ratio were found to be better biomarkers for predicting disease activity. The optimal cut-off value for PCT was 0.244, with a sensitivity of 86.6% and a specificity of 72.2%; the area under the curve (AUC) was 0.797 (p < 0.01). For the PLT/ALB ratio, the cut-off value was 7.80, with a sensitivity of 79.3%, specificity of 72.2%, and an AUC of 0.792 (p < 0.01). Conclusion: PCT and the PLT/ALB ratio, which depend on platelet count, mean platelet volume (MPV), and albumin levels, may serve as independent indices and sensitive biomarkers for identifying active Crohn's disease.