OTUD7B Stabilization by METTL14-Mediated m6A Methylation Drives HIF-1<b>α</b> Expression in Esophageal Squamous Cell Carcinoma

METTL14 plays a crucial role in the stabilization of OTUD7B through m6A methylation, thereby inhibiting the ubiquitin-proteasomal degradation of HIF-1α in ESCC. These findings highlight the potential of targeting the METTL14-OTUD7B axis as a therapeutic strategy for ESCC.

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Publication Details

Journal
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
Published
2025-01-01
DOI
https://doi.org/10.32604/or.2025.061301
Citations
1
Primary Topic
RNA modifications and cancer
Type
article
Field-Weighted Citation Impact
0.81
Controls
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article

OTUD7B Stabilization by METTL14-Mediated m6A Methylation Drives HIF-1α Expression in Esophageal Squamous Cell Carcinoma

Yansen Cai, Yang Song, Fei Ren
1 citations
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
RNA modifications and cancer
0.81
article

OTUD7B Stabilization by METTL14-Mediated m6A Methylation Drives HIF-1α Expression in Esophageal Squamous Cell Carcinoma

Yansen Cai, Yang Song, Fei Ren
article en
1 citations

Abstract

METTL14 plays a crucial role in the stabilization of OTUD7B through m6A methylation, thereby inhibiting the ubiquitin-proteasomal degradation of HIF-1α in ESCC. These findings highlight the potential of targeting the METTL14-OTUD7B axis as a therapeutic strategy for ESCC.

Oncology Research Featuring Preclinical and Clinical Cancer TherapeuticsVol. 33(8)
Changzhi Medical College (CN), Southwest Medical University (CN)
Openalex Percentile: Top 28%
RNA modifications and cancer
0.81
DOIOpen Access PDFOpenAlex
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