INTERPOLAR_MI – A Study Platform Concept for IT-Supported Drug Therapy Safety Research

Pharmacist interventions significantly reduce medication errors and improve drug-therapy safety, with IT-supported workflows, including Clinical Decision Support Systems (CDSS), enhancing real-time decision-making. To address challenges in Germany's federated hospital system, the INTERPOLAR study platform integrates real-world data into routine care workflows. Developed under the Medical Informatics Initiative (MII), the platform leverages a CDS Toolchain with FHIR-based data items, predefined triggers, real-time feedback, and a robust data security framework. The platform supports diverse study designs, aligning technical capabilities with clinical workflows through process mapping and requirements engineering. A centralized health data warehouse enables large-scale analysis while ensuring GDPR compliance. Initial results demonstrate harmonized documentation, improved detection of drug-related problems (DRPs), and efficiency gains via automation. Current studies include medication adherence, ADEs, and pharmacist intervention impacts. By embedding IT-supported workflows into routine care, INTERPOLAR provides a scalable, federated solution for drug-therapy safety research, contributing to global pharmacovigilance and advancing evidence-based medicine.