Antioxidant and anti-wrinkle effects of fermented Houttuynia cordata extract

This study aimed to evaluate the potential of fermented Houttuynia cordata extract as a new material for improving skin conditions by comparing its antioxidant and anti-wrinkle physiological activities after fermentation with the beneficial lactic acid bacteria, Lactobacillus plantarum KCTC 3108. The results showed that the fermented Houttuynia cordata extract (FEEH) exhibited higher total polyphenol and flavonoid content compared to the non-fermented Houttuynia cordata extract (EEH), as well as superior antioxidant activity in 2,2’-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging, ferric reducing antioxidant power (FRAP) activity, and superoxide dismutase (SOD)-like activity. Additionally, FEEH demonstrated higher elastase inhibition rates and collagen production, confirming its excellent anti-wrinkle effects. These findings suggest that the fermentation process can enhance the functional components of Houttuynia cordata extract, increasing its antioxidant activity and skin improvement effects. FEEH shows potential as a natural antioxidant and anti-wrinkle ingredient. Further clinical trials and commercialization strategies should be considered for future research.