Enabling desaturation of lactones by reversible catalytic activity of ‘ene’-reductases
An engineered old yellow enzyme lactone dehydrogenase (OYE1 LD ), which can reversibly catalyze the formation of CC bonds and facilitate the conversion of lactones and ketones into their α,β-unsaturated counterparts, is reported.
Authors
- Fengxi Li (ORCID: https://orcid.org/0000-0003-3613-7845)
- Xinyan Shi (ORCID: https://orcid.org/0000-0003-4671-3981)
- Zhi Wang (ORCID: https://orcid.org/0000-0002-3232-4267)
- Lei Wang (ORCID: https://orcid.org/0000-0002-1931-7767)
- Chuang Du (ORCID: https://orcid.org/0000-0002-6238-1908)
- Xiaoye Yu (ORCID: https://orcid.org/0009-0000-9254-1813)
- Sheng Xie (ORCID: https://orcid.org/0000-0003-3280-9632)
- Zhengqiang Li (ORCID: https://orcid.org/0000-0003-4025-2117)
- Yangyong Dai (ORCID: https://orcid.org/0000-0001-9330-0130)
Institutions
- Jilin University (CN)
- Changchun Institute of Applied Chemistry (CN)
- State Key Laboratory of Polymer Physics and Chemistry (CN)
Publication Details
- Journal
- Green Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5gc01533b
- Citations
- 5
- Primary Topic
- Analytical Chemistry and Chromatography
- Type
- article
- Field-Weighted Citation Impact
- 3.78