COMPARISON OF DIURNAL INDEX AND LIPID PARAMETERS FROM NORMAL INDIVIDUALS AND PATIENTS Of DIABETIS WITH CHRONIC KIDNEY DISEASE

Chronic kidney disease (CKD) heightens the risk of cardiovascular complications and often linked with a non-dipping blood pressure (BP) pattern. We assessed 24 hour ambulatory blood pressure, and lipid profile of diabetic patients suffering from CKD . To determine the frequency of associated risk factors in diabetic CKD patients, A cross-sectional research design was employed at ERA’s Lucknow Medical College and Hospital for this study. We recruited 184 patients with diabetic CKD Patients (mean age, 60.9±12.0 years). After adjusting for age and sex, hypertension and lipid profile showed a significant association with CKD. Levels of triglycerides (TG), very-low-density lipoprotein (VLDL), total cholesterol, and low-density lipoprotein (LDL) were elevated in CKD cases in comparison to normal individuals, whereas high-density lipoprotein (HDL) and estimated glomerular filtration rate (eGFR) were notably lower in the cases. On analysis of data, HDL level was decreased in CKD patients and correlation was statistically significant (p<0.001).LDL level was found to be higher in cases than in CKD patients, this correlation was also significant with p value less than 0.001. In the cases total cholesterol level was found to be elevated that is in CKD patients and the association was scientifically significant (p<0.001). In cases the level of triglceride was also more that are in CKD patients and the association was significantly correlated (p<0.001).In addition, Dipping was maximum in control groups (70.7%) while non-dipping was maximum in the case group (75%). A significant association of dipping was found with the case (p<0.001).