Evaluation of the Antitumoral Effect of PI3K/AKT/mTOR Pathway Inhibition and Antioxidant Combination on Burkitt Lymphoma Cell Line
Our study showed that ETP 45668 alone and in combination with resveratrol has antitumoral activity on the Burkitt lymphoma cell line. PI3K/Akt/mTOR pathway inhibitors may be an alternative treatment option in patients with relapsed/refractory Burkitt lymphoma. However, more preclinical and clinical studies are needed.
Authors
- Mehmet Şencan (ORCID: https://orcid.org/0000-0002-1459-3906)
- İbrahim KARADUMAN
- Şeyma Taştemur (ORCID: https://orcid.org/0000-0002-9013-6395)
- Hatice Terzi (ORCID: https://orcid.org/0000-0003-3471-1305)
Institutions
- Sivas Cumhuriyet Üniversitesi (TR)
- Gazi University (TR)
Publication Details
- Journal
- Current Cancer Drug Targets
- Published
- 2025-05-15
- DOI
- https://doi.org/10.2174/0115680096366040250414114030
- Citations
- 1
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81