SLE-DAS enables an accurate definition of severe lupus disease activity: derivation and validation in a post hoc study of anifrolumab phase II and III studies
The SLE-DAS cut-off for SDA provides an accurate definition of SDA in SLE, with good discriminative power and consistent associations with worse HR-QoL. This SLE-DAS definition enhances disease activity classification and offers a practical tool for guiding treatment decisions in clinical practice, as well as selecting patients with SDA for inclusion in clinical trials.
Authors
- Luís Inês (ORCID: https://orcid.org/0000-0003-3172-3570)
- Ana Matos (ORCID: https://orcid.org/0000-0001-6408-5857)
- Carla Henriques (ORCID: https://orcid.org/0000-0002-2142-2849)
- Andrea Doria (ORCID: https://orcid.org/0000-0003-0548-4983)
- Diogo Jesús (ORCID: https://orcid.org/0000-0003-3136-0722)
Institutions
- University of Padua (IT)
- University of Beira Interior (PT)
- Instituto Politécnico de Leiria (PT)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Polytechnic Institute of Viseu (PT)
- University of Coimbra (PT)
Publication Details
- Journal
- Lupus Science & Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/lupus-2025-001499
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00