Clinicogenomic Characterization of Inflammatory Breast Cancer
This study provides a comprehensive resource of somatic alterations in a large cohort of patients with metastatic IBC and non-IBC, highlighting genomic features associated with worse outcomes. Our findings reveal a significant enrichment of TP53 mutations, reinforcing its critical role in IBC pathogenesis. Few other distinct differences in IBC were observed, suggesting further investigations-beyond bulk sequencing of the somatic genome-are required to better understand the biology driving this aggressive disease.
Authors
- Jennifer R. Bellon (ORCID: https://orcid.org/0000-0001-6241-0230)
- Filipa C. Lynce (ORCID: https://orcid.org/0000-0001-6615-7076)
- Gregory John Kirkner (ORCID: https://orcid.org/0009-0005-0386-5223)
- Melissa E. Hughes (ORCID: https://orcid.org/0000-0001-6190-9101)
- Faina Nakhlis (ORCID: https://orcid.org/0000-0003-4752-0161)
- Janet Files
- Ana C. Garrido-Castro (ORCID: https://orcid.org/0000-0002-5989-6636)
- Beth Harrison (ORCID: https://orcid.org/0000-0002-8341-2961)
- Andrew D. Cherniack (ORCID: https://orcid.org/0000-0003-0470-0111)
- Ayesha Mohammed-Abreu
- Nolan Priedigkeit (ORCID: https://orcid.org/0000-0001-8330-5210)
- Brittany Bychkovsky (ORCID: https://orcid.org/0000-0001-7969-0603)
- Neal I. Lindeman (ORCID: https://orcid.org/0000-0002-7092-6859)
- Anne-Marie Feeney
- Marie Claire Remolano
- Nancy U. Lin (ORCID: https://orcid.org/0000-0003-2263-5413)
- Liam F. Spurr (ORCID: https://orcid.org/0000-0001-6465-7739)
- Bruce E. Johnson (ORCID: https://orcid.org/0000-0002-5252-3677)
- Deborah Dillon (ORCID: https://orcid.org/0000-0002-4977-6673)
- Sara M. Tolaney (ORCID: https://orcid.org/0000-0002-5940-8671)
- Eric P. Winer (ORCID: https://orcid.org/0000-0002-8819-1723)
- Romualdo Barroso‐Sousa (ORCID: https://orcid.org/0000-0002-1825-9876)
- Yvonne Li (ORCID: https://orcid.org/0000-0002-1741-1995)
- Tari A. King (ORCID: https://orcid.org/0000-0003-3602-2351)
- Beth Overmoyer (ORCID: https://orcid.org/0000-0003-4438-7000)
- Lynette M. Sholl (ORCID: https://orcid.org/0000-0002-9532-9735)
- Robert Shue
- Alinés Lebrón-Torres (ORCID: https://orcid.org/0009-0004-9739-0881)
- Libby Grant
- Sarah Strauss
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Cornell University (US)
- Dana-Farber Cancer Institute (US)
- Dana-Farber/Harvard Cancer Center (US)
- Hospital Universitário de Brasília (BR)
- Dana-Farber Brigham Cancer Center (US)
- Weill Cornell Medicine (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2081
- Citations
- 2
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- American Association for Cancer Research
- Conquer Cancer Foundation
- Pan-Massachusetts Challenge
- Susan G. Komen