Prediabetes: Risk factors instead of complaints?

Prediabetes is a clinical condition characterized by impaired glucose tolerance, insulin resistance, and an increased risk of developing type 2 diabetes mellitus. In addition to its progression to diabetes, prediabetes is an independent risk factor for cardiovascular diseases (CVD) due to a complex of pathophysiological mechanisms, including endothelial dysfunction, chronic inflammation, and lipid metabolism disorders. Moreover, the presence of CVD itself can contribute to worsening insulin sensitivity, thereby increasing the likelihood of developing prediabetes. This article presents current data on the epidemiology, pathogenesis, diagnostic methods, and pharmacotherapy of prediabetes, along with a comparative analysis of pharmacological approaches, including Subetta ® , metformin and GLP-1 receptor agonists.