TNFRSF11B-modified umbilical cord mesenchymal stem cells as a novel strategy for bone-related diseases by suppressing osteoclast activity
This study demonstrates that although TNFRSF11B overexpression does not promote osteogenesis in UCMSCs, it may participate in regulating bone remodeling by inhibiting osteoclast differentiation.
Authors
- Jian V. Zhang (ORCID: https://orcid.org/0000-0002-1700-9664)
- Junyuan Hu (ORCID: https://orcid.org/0009-0002-7306-1077)
- Mina Ding (ORCID: https://orcid.org/0000-0002-7114-738X)
- Pei Ke (ORCID: https://orcid.org/0000-0001-7554-5636)
- Liang Wang (ORCID: https://orcid.org/0000-0003-3045-4903)
- Liao Yan
- Zhijie Liu (ORCID: https://orcid.org/0000-0002-1848-378X)
- Qian Ding (ORCID: https://orcid.org/0000-0002-5961-5945)
Institutions
- Chinese Academy of Sciences (CN)
- Beike Biotechnology (China) (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Biotechnology Research Institute (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1186/s13018-025-05850-9
- Citations
- 3
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 4.88
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province