Dual-source powered sea urchin-like nanomotors for intravesical photothermal therapy of bladder cancer
Bladder cancer (BCa) ranks as the 9th most prevalent malignancy worldwide, featured by its high risk of recurrence. Intravesical therapy constitutes the most important modality to tackle BCa, but its efficiency is often compromised due to the dense physiological barriers in BCa, the instability of the catalytic environment, and the rapid clearance facilitated by periodic urination. Here, we present a dual-source powered sea urchin-like nanomotor, which feature a gold nanocore decorated with ultrasmall platinum nanoparticles and ureases, enable rapid propulsion through the catalytic conversion of abundant urea and hydrogen peroxide present in the bladder cavity and BCa microenvironment, respectively. Our dual-source powered Au-Pt@ur NPs nanoparticles translocated across the mucus barrier rapidly, deeply penetrated tumor and hence chemo-resected bladder tumors in all cases. These results hold substantial promise for the development of biocompatible nanomotors for improved BCa intravesical therapy.
Authors
- Jiajia Zheng (ORCID: https://orcid.org/0000-0001-8997-8862)
- Xiaolong Qi (ORCID: https://orcid.org/0000-0002-3559-5855)
- Jinhai Fan (ORCID: https://orcid.org/0000-0002-0153-1159)
- Yuchen Bai (ORCID: https://orcid.org/0000-0002-3389-7104)
- Zhenghong Liu (ORCID: https://orcid.org/0000-0003-3361-3818)
- Haichang Li (ORCID: https://orcid.org/0000-0001-9784-6480)
- Lei Wang (ORCID: https://orcid.org/0000-0002-7067-3732)
- Wentao Xu (ORCID: https://orcid.org/0000-0002-4394-2204)
- Xiaowen Qin (ORCID: https://orcid.org/0009-0002-2652-1034)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-5055-3637)
- Pu Zhang (ORCID: https://orcid.org/0000-0002-4020-6148)
- Bin Zheng (ORCID: https://orcid.org/0000-0002-9984-4136)
- Dahong Zhang (ORCID: https://orcid.org/0000-0003-0372-1164)
- Minghai Ma (ORCID: https://orcid.org/0009-0003-6388-7120)
- Yixuan Mou (ORCID: https://orcid.org/0000-0003-4776-932X)
- Ran Ni
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- First Affiliated Hospital of Jinan University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1186/s12951-025-03446-3
- Citations
- 4
- Primary Topic
- Micro and Nano Robotics
- Type
- article
- Field-Weighted Citation Impact
- 5.03
Funders
- National Natural Science Foundation of China