DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway
PLTP regulates the proliferation, migration and tube formation of HRMECs, and is involved in maintaining vascular function via the AKT/GSK3β signaling pathway. In HG environment, increased DNMT3B expression upregulates DNA methylation of the PLTP promoter, downregulating PLTP expression and leading to vascular dysfunction in DR.
Authors
- Shuai He (ORCID: https://orcid.org/0000-0001-6619-1039)
- Qingquan Wei
- Qinghua Qiu (ORCID: https://orcid.org/0000-0002-8383-892X)
- Chunyang Cai
- Chunren Meng
- Chufeng Gu (ORCID: https://orcid.org/0000-0003-1038-1372)
- Yujie Wang (ORCID: https://orcid.org/0000-0001-7277-7992)
- Tengfei Wang (ORCID: https://orcid.org/0000-0002-1253-0514)
- Xinyun Wang (ORCID: https://orcid.org/0000-0002-5377-2026)
- Dongwei Lai (ORCID: https://orcid.org/0000-0002-9568-8463)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Centre for Eye Research Australia (AU)
- Tongren Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1186/s13148-025-01874-4
- Citations
- 3
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.12
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China