Inhibition of DLK1 regulates AT2 differentiation and alleviates established pulmonary fibrosis by upregulating TTF-1/CLDN6
DLK1 inhibition regulates AT2 differentiation and contributes to the mitigation of established fibrosis via TTF-1/CLDN6 pathway, which suggests that DLK1 may be a therapeutic target for IPF.
Authors
- Enhao Wang (ORCID: https://orcid.org/0000-0002-0669-7924)
- Jiaxing Sun (ORCID: https://orcid.org/0000-0001-8372-5784)
- Xuan Liu (ORCID: https://orcid.org/0000-0003-3046-1046)
- Chunmei Wang (ORCID: https://orcid.org/0000-0001-8576-2933)
- Chen Zhou (ORCID: https://orcid.org/0000-0002-7286-3740)
- Jianwen Bai (ORCID: https://orcid.org/0000-0001-7178-0057)
- Xiaohui Zhou (ORCID: https://orcid.org/0000-0001-7491-628X)
- Yinzhen Li
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1186/s12931-025-03264-z
- Citations
- 4
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- National Natural Science Foundation of China