Multivariable prediction of early malignancy detection among first-degree relatives of patients with hereditary colorectal cancer based on the health belief model: A cross-sectional study from the largest hereditary colorectal cancer cohort in China

The uptake of malignancy early detection among FDRs should be improved. Some demographic and health-related characteristics, knowledge score, perceived susceptibility and self-efficacy were the most important predictors of malignancies early detection. Enhancing the recognition of clinical features of hereditary CRC and offering personalized genetic counseling, along with tailored cancer risk assessments, could further optimize individual cancer surveillance and prevention strategies, helping to reduce the risk of malignancies in high-risk populations.